Kaley Cuoco and Johnny Galecki
"Penny" and "Leonard" from "The Big Bang Theory" did not only hook up on-screen, but fell in love in real life as well. However, Kaley Cuoco and Johnny Galecki kept their relationship a secret until they separated in 2010. Johnny is now dating Ariella Nicole, while Kaley is single, after being married to Ryan Sweeting for two years.